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            • Aeromexico Rewards Chart
            • Get Avios Points Free
        • Today Bitcoin Price at $6,800 USD
        • Pandemic Is Changing BTC Usage in ‘Unexpected Ways’
        • Macropay on Alternative & local payment methods that are reshaping global e-commerce
        • Bank of America is preparing for a flood of Applications to Small-Business Loan
        • Microsoft might be the best tech stock in this market
        • US Airlines To Work Collectively, Consolidate Flights
        • Bank of America maintaining business continuity and protecting the bottom line
        • US long-term mortgage rates drop
        • Bitcoin Price Bulls have been rejected at $7,000
        • Stock Market: 4 Top Stock Trades for Wednesday: NVDA, AVGO, BAC, IQ
        • Stock Market April 2 – Edge Higher; Oil Surges, Bonds Fall, Dollar Rose
        • Chase bank will raise up to $10 billion
          • Bitcoin Price Simply Surged to $6,500 After Over 10% Weekend Crash
          • Today Bitcoin Price at $7,000: BTC Leaps to Retest $7,000
          • Bank of America agreed to allow 50,000 mortgage customers to defer payments
        • Bitcoin Price Prediction April: Three Key Causes Why BTC May Plunge Beneath $5,000
          • Roll up the Sleeves! American Airlines was down -10.34%
          • Mortgage calculator rates today April 2, 2020
          • Mortgage Calculator Small businesses: SB have ‘a million inquiries’ regarding check help loans
          • Bitcoin Price Today April 1 – Bitcoin Takes Tumble
            • With Bank of America card you can request a payment deferral online
              • Bank of America fields 150,000 installment deferral demands
            • Coronavirus – Travel Insurance no cover cancellations
              • Bank of America said it won’t cut any positions
          • Bitcoin Price Today April 2 – BTC rise to $6,700
          • Mortgage calculator rates today March 31, 2020
          • Bitcoin Price Momentum Sign Reverses, Bull Run Lastly Inbound?
          • Bitcoin Price Recovering After a Sharp Decline
          • Fintech News Airbnb – How hosts are fighting back against Covid-19 fallout
          • Market Stock Boeing – Challenging Times Ahead for Boeing Stock
        • Bank of America U.S. Minimum Hourly Wage Reaches $20
          • Bitcoin Price Bulls – is Forming a Bull Cross After Rallying to $6,500
          • P2P Crowdlending – Average Interest Rate 18%
          • $633 Million BTC Transferred For Simply $0.26 Payment
        • Prime ICO Advertising and marketing Companies
        • Bank of America will provide up to $250 million
        • Bank of America VC: You tend to do the wrong thing at the wrong time
          • Bitcoin Price Jump as Coronavirus Curve Begins to Flatten
            • Bitcoin Price Today April 3
            • Bitcoin Price Is Sometimes Bullish in Q2
            • Bitcoin Price Tumble Beneath $ 6,000
            • BTC Price Today 5 | April, 2020
            • Bitcoin Price and S&P 500 – Here’s how much bitcoin beat the Dow and S&P 500 in the first quarter
              • Today Bitcoin Price at $6,600
                • Bitcoin Price Bulls Reaches: “Live or Die”
                • BTC Price Today | 6 April 2020
          • Bank of America sees big year for Microsoft ahead
            • American Airlines coronavirus downgrade
              • Bitcoin Price Rejected $6,600
              • Bitcoin Price Trace It Will Fall to $ 5 K
              • BTC Price Today April 4
                • Stock Market Today 31 March, 2020
              • US Bank Raises $586M Against COVID-19
                • Bank of America’s Solid Liquidity to Help Covid-19 Crisis
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      • Mortgage calculator rates today April 1, 2020
      • Mortgage Calculator – Students Benefits
      • Mortgage Calculator – Homeowners and renters Get Payment Relief
      • Calculator for mortgage to millennials
      • Mortgage Calculator Modification – What Is?
      • Mortgage Calculator Canada: Rates Are Rising
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        • Mortgage rates today, April 3, 2020 plus reviews
          • cmc currency details
            • cmc exchange details
              • Shortcodes
        • Microsoft Vulnerability: Hundreds of Microsoft Servers Contaminated By Crypto-Mining Botnet Since 2018
          • Cision PR Newswire
          • Coupons – Best websites
            • Aeromexico Rewards Chart
            • Get Avios Points Free
        • Today Bitcoin Price at $6,800 USD
        • Pandemic Is Changing BTC Usage in ‘Unexpected Ways’
        • Macropay on Alternative & local payment methods that are reshaping global e-commerce
        • Bank of America is preparing for a flood of Applications to Small-Business Loan
        • Microsoft might be the best tech stock in this market
        • US Airlines To Work Collectively, Consolidate Flights
        • Bank of America maintaining business continuity and protecting the bottom line
        • US long-term mortgage rates drop
        • Bitcoin Price Bulls have been rejected at $7,000
        • Stock Market: 4 Top Stock Trades for Wednesday: NVDA, AVGO, BAC, IQ
        • Stock Market April 2 – Edge Higher; Oil Surges, Bonds Fall, Dollar Rose
        • Chase bank will raise up to $10 billion
          • Bitcoin Price Simply Surged to $6,500 After Over 10% Weekend Crash
          • Today Bitcoin Price at $7,000: BTC Leaps to Retest $7,000
          • Bank of America agreed to allow 50,000 mortgage customers to defer payments
        • Bitcoin Price Prediction April: Three Key Causes Why BTC May Plunge Beneath $5,000
          • Roll up the Sleeves! American Airlines was down -10.34%
          • Mortgage calculator rates today April 2, 2020
          • Mortgage Calculator Small businesses: SB have ‘a million inquiries’ regarding check help loans
          • Bitcoin Price Today April 1 – Bitcoin Takes Tumble
            • With Bank of America card you can request a payment deferral online
              • Bank of America fields 150,000 installment deferral demands
            • Coronavirus – Travel Insurance no cover cancellations
              • Bank of America said it won’t cut any positions
          • Bitcoin Price Today April 2 – BTC rise to $6,700
          • Mortgage calculator rates today March 31, 2020
          • Bitcoin Price Momentum Sign Reverses, Bull Run Lastly Inbound?
          • Bitcoin Price Recovering After a Sharp Decline
          • Fintech News Airbnb – How hosts are fighting back against Covid-19 fallout
          • Market Stock Boeing – Challenging Times Ahead for Boeing Stock
        • Bank of America U.S. Minimum Hourly Wage Reaches $20
          • Bitcoin Price Bulls – is Forming a Bull Cross After Rallying to $6,500
          • P2P Crowdlending – Average Interest Rate 18%
          • $633 Million BTC Transferred For Simply $0.26 Payment
        • Prime ICO Advertising and marketing Companies
        • Bank of America will provide up to $250 million
        • Bank of America VC: You tend to do the wrong thing at the wrong time
          • Bitcoin Price Jump as Coronavirus Curve Begins to Flatten
            • Bitcoin Price Today April 3
            • Bitcoin Price Is Sometimes Bullish in Q2
            • Bitcoin Price Tumble Beneath $ 6,000
            • BTC Price Today 5 | April, 2020
            • Bitcoin Price and S&P 500 – Here’s how much bitcoin beat the Dow and S&P 500 in the first quarter
              • Today Bitcoin Price at $6,600
                • Bitcoin Price Bulls Reaches: “Live or Die”
                • BTC Price Today | 6 April 2020
          • Bank of America sees big year for Microsoft ahead
            • American Airlines coronavirus downgrade
              • Bitcoin Price Rejected $6,600
              • Bitcoin Price Trace It Will Fall to $ 5 K
              • BTC Price Today April 4
                • Stock Market Today 31 March, 2020
              • US Bank Raises $586M Against COVID-19
                • Bank of America’s Solid Liquidity to Help Covid-19 Crisis
  • Lifestyle
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      • 6% cd rates – They Exists ?
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      • Capital One Credit Card – Best Cards of 2020
      • Best Credit Cards for Students 2020
      • Best Airline Credit Card 2020
      • Best Gas Rewards Credit Cards of 2020
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      • Best Travel Credit Card 2020
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      • Best Secured Credit Cards 2020
      • Best Credit Cards for Bad Credit 2020
      • Best Rewards Credit Card 2020
      • Best 0% APR Credit Cards of February 2020
      • The Best Credit Card for Balance Transfers 2020
      • Best Buy Credit Card 2020
      • Best Credit Cards of July 2020
      • 11 Best Prepaid Debit Cards of 2020
      • Best Business Credit Cards 2020
    • Cards
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      • Lowe’s Credit Card
      • Get Revolut Card + £50
      • Qantas Credit Card
      • Chase Credit Card
      • Coles Mastercard
      • Capital One
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    • Credit Cards Guides
      • How many credit cards should I have?
      • Is Discover Visa or Mastercard?
    • Credit Cards Reviews
      • First Premier Credit Card Review
      • Fortiva Credit Card Review
      • Indigo Credit Card Review
      • Wells Fargo Propel – Review
      • Walmart Money Card – Review
      • Credit One Credit Card Review
      • Discover it® Cash Back – Review
      • Travel credit card reviews 2020
      • Petal Credit Card Review
      • Apple Credit Card Review
      • Capital One Venture Rewards Credit Card Review
      • Amazon Credit Card Review
  • Politics
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      • Joe Biden
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      • Scott Morrison
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      • Angela Merkel
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  • Mortgages
    • Mortgage “Best of…”
      • Best Mortgage for Low Down Payment 2020
      • Best Mortgage Rates
      • Best VA Mortgage Lenders of 2020
      • Greatest On-line Mortgage Lenders
      • The Best Mortgage Lenders for First Time Home Buyers
    • Mortgage Calculators
      • Mortgage calculator rates today April 1, 2020
      • Mortgage Calculator – Students Benefits
      • Mortgage Calculator – Homeowners and renters Get Payment Relief
      • Calculator for mortgage to millennials
      • Mortgage Calculator Modification – What Is?
      • Mortgage Calculator Canada: Rates Are Rising
      • Mortgage Calculator Home – Is it time to repair your own home mortgage?
      • Mortgage Calculator
      • Mortgage Calculator Rates Today April 3
      • Mortgage Calculator Online
      • Mortgage Calculator Coronavirus: UK mortgage market goes into lockdown
    • Mortgage Guides
      • Lending
      • How Mortgage Forbearance Works Under CARES Act
      • Stimulus Check
    • Mortgage Companies
      • Nationstar Mortgage
      • Roundpoint Mortgage
      • Midland Mortgage
      • Simple Mortgage Calculator
      • Freedom Mortgage
      • SunTrust Mortgage
  • Commodities
    • Energy
      • WTI Oil Prices
      • Brent Crude
      • Crude Oil
    • Agricultural Products
      • Corns
    • Livestock & Meat
      • Lean Hogs
    • Precious Metals
      • Platinum
      • Gold
        • Best Place to Buy Gold
        • Price of Gold
        • 5 Ways In order to Buy Gold
        • Gold Price Chart
        • Gold Futures
      • Silver
    • Industrial Metals
      • Copper
  • Insurtech
    • Insurtech “Best of…”
      • Best Life Insurance of 2020
      • The Best Renters Insurance Companies 2020
      • Best Pet Insurance Providers of 2020
      • Best Home Insurance Companies for 2020
      • Best Car Insurance Quotes Online
      • Best Homeowners Insurance Companies of 2020
    • Insurtech Guides
      • Insurance will not cover coronavirus losses
  • Loans
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      • First time loan with no credit
      • Find the Best Private Lender for Personal Loans
      • Emergency personal loans for veterans
      • Fafsa deadline
      • Cash Loans
      • Bad Credit Loans
      • Bad Credit Loans Guaranteed Approval
      • Merrill Lynch Benefits
      • Loans CLO Pain Just Starting With Leveraged loan Rating Cuts
      • Can you get a loan without a bank account?
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AstraZeneca – Ionis proclaims AstraZeneca’s initiation of the Part 2b scientific examine of its antisense medication concentrating on PCSK9 to decrease LDL-cholesterol

Judie Simms by Judie Simms
November 30, 2020
in AstraZeneca
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Home » AstraZeneca – Ionis proclaims AstraZeneca’s initiation of the Part 2b scientific examine of its antisense medication concentrating on PCSK9 to decrease LDL-cholesterol

AstraZeneca – Ionis proclaims AstraZeneca‘s initiation of the Part 2b scientific examine of its antisense medication concentrating on PCSK9 to decrease LDL-cholesterol

CARLS(BA)D, Calif., Nov. 30, 2020 /PRNewswire/ — Ionis Prescription drugs, Inc. (NASDAQ: IONS) in the present day introduced that the biopharmaceutical firm AstraZeneca has initiated a Part 2b scientific trial of ION449 (AZD8233), an investigational antisense medication designed to cut back blood levels of cholesterol in sufferers with dyslipidemia by concentrating on proprotein convertase subtilisin/kexin kind 9 (PCSK9), an essential regulator of low-density lipoprotein ldl cholesterol (LDL-C). PCSK9 is an enzyme that controls the variety of LDL receptors on the floor of cells. Folks with genetic variations that scale back PCSK9 operate have decrease LDL-C ranges within the blood and a decrease danger for main cardiovascular occasions. ION449 is a LIgand Conjugated Antisense (LICA) medication being developed by AstraZeneca as a part of a collaboration between Ionis and AstraZeneca.

The Part 2b, randomized, double-blind, placebo-controlled trial will enroll roughly 108 contributors, aged 18-75, who’ve LDL-C ranges between 70 and 190 mg/dL and are receiving moderate- or high-intensity statin remedy as outlined by the American School of Cardiology/American Coronary heart Affiliation (ACC/AHA) pointers on blood ldl cholesterol administration. The first goal is to evaluate the impact of various doses of ION449 on LDL-C in comparison with placebo at Week 12 in sufferers taking baseline statin remedy.  The examine will consider three dose ranges of ION449 versus placebo, all administered as soon as a month by subcutaneous injection. Security and tolerability shall be evaluated together with quite a lot of secondary endpoints. Study extra in regards to the trial at: https://clinicaltrials.gov/ct2/present/NCT04641299. 

In a Part 1 examine reported on the American Coronary heart Affiliation (AHA) Scientific Classes on November 13, single subcutaneous doses of ION449 (AZD8233) demonstrated dose-dependent imply reductions in circulating plasma PCSK9 and LDL-C ranges of >90 % and as much as 70 %, respectively, in topics who had a baseline LDL-C between 100 and 190 mg/dL with out concomitant statin remedy.1  Doses as much as 120 mg have been evaluated. ION449 was noticed to be protected and well-tolerated in any respect dose ranges. 

“Outcomes from the Part 1 examine confirmed that ION449 potently reduces PCSK9 and LDL ldl cholesterol. ION449 demonstrated best-in-class potential for PCSK9 inhibition and LDL-C discount, supporting bigger scientific trials that at the moment are underway to additional consider efficacy and security,” stated Sotirios “Sam” Tsimikas, M.D., senior vice chairman, scientific growth and cardiovascular franchise chief at Ionis. “The rising proof supporting Ionis’ superior LICA expertise in heart problems holds promise for simpler approaches to decrease LDL-C and to deal with heart problems, the main reason behind dying worldwide.”

Dr. Tsimikas will present an replace on Ionis’ cardiovascular applications throughout Ionis’ Digital Investor Day, Dec. 7, 2020, starting at 12 p.m. EST.

Ionis earned a milestone fee of $20 million from AstraZeneca for the Part 2b scientific trial initiation of ION449. Ionis and AstraZeneca are collaborating on potential therapies for kidney illness, cardiometabolic illness and most cancers.

About Ionis Prescription drugs, Inc.

Because the chief in RNA-targeted drug discovery and growth, Ionis has created an environment friendly, broadly relevant, drug discovery platform referred to as antisense expertise that may deal with illnesses the place no different therapeutic approaches have confirmed efficient. Our drug discovery platform has served as a springboard for actionable promise and realized hope for sufferers with unmet wants. We created the primary and solely accepted remedy for all sufferers, youngsters and adults with spinal muscular atrophy, in addition to the world’s first RNA-targeted therapeutic accepted for the remedy of polyneuropathy in adults with hereditary transthyretin amyloidosis. Our sights are set on all of the sufferers we have now but to succeed in with a pipeline of greater than 40 novel medicines designed to probably deal with a broad vary of illness, together with neurological, cardio-renal, metabolic, infectious, and pulmonary illnesses.

To be taught extra about Ionis go to www.ionispharma.com and observe us on Twitter @ionispharma.

Ionis’ Ahead-looking Assertion

This press launch contains forward-looking statements relating to Ionis’ enterprise and the therapeutic and business potential of ION449 (AZD8233), Ionis’ applied sciences and merchandise in growth. Any assertion describing Ionis’ targets, expectations, monetary or different projections, intentions or beliefs is a forward-looking assertion and ought to be thought of an at-risk assertion. Such statements are topic to sure dangers and uncertainties, together with these associated to the affect COVID-19 might have on our enterprise, and together with however not restricted to these associated to our business merchandise and the medicines in our pipeline, and significantly these inherent within the strategy of discovering, creating and commercializing medicines which might be protected and efficient to be used as human therapeutics, and within the endeavor of constructing a enterprise round such medicines. Ionis’ forward-looking statements additionally contain assumptions that, in the event that they by no means materialize or show right, might trigger its outcomes to vary materially from these expressed or implied by such forward-looking statements. Though Ionis’ forward-looking statements replicate the great religion judgment of its administration, these statements are based mostly solely on info and components presently identified by Ionis. In consequence, you might be cautioned to not depend on these forward-looking statements. These and different dangers regarding Ionis’ applications are described in further element in Ionis’ annual report on Type 10-Okay for the 12 months ended December 31, 2019, and the latest Type 10-Q quarterly submitting, that are on file with the SEC. Copies of those and different paperwork can be found from the Firm.

On this press launch, except the context requires in any other case, “Ionis,” “Firm,” “we,” “our,” and “us” refers to Ionis Prescription drugs and its subsidiaries.

Ionis Pharmaceuticalsä is a trademark of Ionis Prescription drugs, Inc.

1 Medical examine (NCT03593785), sponsored by AstraZeneca.

SOURCE Ionis Prescription drugs, Inc.

Associated Hyperlinks

http://www.ionispharma.com

Tags: Clinical Trials & Medical DiscoveriesHealth Care & HospitalsIncIonis PharmaceuticalsMedical PharmaceuticalsPharmaceuticals
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