But the positive news was offset by other results that showed it offered significantly less protection against a highly transmissible variant of the coronavirus first identified in South Africa, which is spreading rapidly around the world.
Novavax said it began working on new vaccines against emerging strains in early January and expects to select ideal candidates in the coming days, then begin clinical testing in the second quarter of the year.
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“NVX-CoV2373 has the potential to play an important role in solving this global public health crisis,” said the company’s president and CEO Stanley Erck, using Novavax’s name for the vaccine.
“We look forward to continuing to work with our partners, collaborators, investigators and regulators around the world to make the vaccine available as quickly as possible.”
British Prime Minister Boris Johnson tweeted that the results were “good news.”
“Our medicines regulator will now assess the vaccine, which will be made in Teesside. If approved, we have 60m doses on order,” he added.
The vaccine was one of six candidates backed by a US government project formerly known as Operation Warp Speed, which has provided the company $1.75 billion. It’s also being tested in a trial in the US and Mexico, which has recruited 16,000 of 30,000 participants.
Unlike the Pfizer, Moderna and AstraZeneca vaccines, which deliver the genetic instructions to make a protein of the virus to human cells, the Novavax shot injects the same molecules directly into the body to evoke an immune response.
S. Africa variant reinfection worry
The British trial involved 15,000 people aged 18 to 84, including 27% who were over the age of 65.
The first interim analysis was based on 62 cases, of which 56 cases of Covid-19 were observed in the placebo group versus six cases among people who received NVX-CoV2373.
The company’s preliminary analysis indicated the variant first identified in Britain, B.1.1.7, was detected in more than 50% of the confirmed cases.
Efficacy by strain was calculated at 95.6% against the original Covid strain, and 85.6% against B.1.1.7.
But the efficacy was much lower in a smaller, mid-stage trial conducted in South Africa.
This study enrolled just over 4,400 patients from September to mid-January, during which time the B.1.351 variant, which contains critical mutations along the virus’ spike protein, was spreading rapidly through the country.
Overall efficacy was 49.4% in this trial, but the figure rose to 60% among the 94% of trial participants who were HIV-negative.
Worryingly, Novavax said about a third of participants in the South Africa trial had been previously infected with the original form of the virus, while the subsequent infections during the study were largely from the variant.
The studies are the first to assess how vaccines performed against both the UK and South Africa variants in the real world.
The US said Thursday it had found its first two cases of the B.1.351 variant on American soil, leading to concern it could reignite the national infection rate, which is currently in decline.
Novavax’s announcement puts pressure on another vaccine maker, Johnson & Johnson, which is expected to announce its phase 3 trial results next week.