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      • Mortgage rates today, April 3, 2020 plus reviews
        • cmc currency details
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      • Microsoft Vulnerability: Hundreds of Microsoft Servers Contaminated By Crypto-Mining Botnet Since 2018
        • Cision PR Newswire
        • Coupons – Best websites
          • Aeromexico Rewards Chart
          • Get Avios Points Free
      • Today Bitcoin Price at $6,800 USD
      • Pandemic Is Changing BTC Usage in ‘Unexpected Ways’
      • Macropay on Alternative & local payment methods that are reshaping global e-commerce
      • Bank of America is preparing for a flood of Applications to Small-Business Loan
      • Microsoft might be the best tech stock in this market
      • US Airlines To Work Collectively, Consolidate Flights
      • Bank of America maintaining business continuity and protecting the bottom line
      • US long-term mortgage rates drop
      • Bitcoin Price Bulls have been rejected at $7,000
      • Stock Market: 4 Top Stock Trades for Wednesday: NVDA, AVGO, BAC, IQ
      • Stock Market April 2 – Edge Higher; Oil Surges, Bonds Fall, Dollar Rose
      • Chase bank will raise up to $10 billion
        • Bitcoin Price Simply Surged to $6,500 After Over 10% Weekend Crash
        • Today Bitcoin Price at $7,000: BTC Leaps to Retest $7,000
        • Bank of America agreed to allow 50,000 mortgage customers to defer payments
      • Bitcoin Price Prediction April: Three Key Causes Why BTC May Plunge Beneath $5,000
        • Roll up the Sleeves! American Airlines was down -10.34%
        • Mortgage calculator rates today April 2, 2020
        • Mortgage Calculator Small businesses: SB have ‘a million inquiries’ regarding check help loans
        • Bitcoin Price Today April 1 – Bitcoin Takes Tumble
          • With Bank of America card you can request a payment deferral online
            • Bank of America fields 150,000 installment deferral demands
          • Coronavirus – Travel Insurance no cover cancellations
            • Bank of America said it won’t cut any positions
        • Bitcoin Price Today April 2 – BTC rise to $6,700
        • Mortgage calculator rates today March 31, 2020
        • Bitcoin Price Momentum Sign Reverses, Bull Run Lastly Inbound?
        • Bitcoin Price Recovering After a Sharp Decline
        • Fintech News Airbnb – How hosts are fighting back against Covid-19 fallout
        • Market Stock Boeing – Challenging Times Ahead for Boeing Stock
      • Bank of America U.S. Minimum Hourly Wage Reaches $20
        • Bitcoin Price Bulls – is Forming a Bull Cross After Rallying to $6,500
        • P2P Crowdlending – Average Interest Rate 18%
        • $633 Million BTC Transferred For Simply $0.26 Payment
      • Prime ICO Advertising and marketing Companies
      • Bank of America will provide up to $250 million
      • Bank of America VC: You tend to do the wrong thing at the wrong time
        • Bitcoin Price Jump as Coronavirus Curve Begins to Flatten
          • Bitcoin Price Today April 3
          • Bitcoin Price Is Sometimes Bullish in Q2
          • Bitcoin Price Tumble Beneath $ 6,000
          • BTC Price Today 5 | April, 2020
          • Bitcoin Price and S&P 500 – Here’s how much bitcoin beat the Dow and S&P 500 in the first quarter
            • Today Bitcoin Price at $6,600
              • Bitcoin Price Bulls Reaches: “Live or Die”
              • BTC Price Today | 6 April 2020
        • Bank of America sees big year for Microsoft ahead
          • American Airlines coronavirus downgrade
            • Bitcoin Price Rejected $6,600
            • Bitcoin Price Trace It Will Fall to $ 5 K
            • BTC Price Today April 4
              • Stock Market Today 31 March, 2020
            • US Bank Raises $586M Against COVID-19
              • Bank of America’s Solid Liquidity to Help Covid-19 Crisis
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      • Mortgage calculator rates today April 1, 2020
      • Mortgage Calculator – Students Benefits
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      • Calculator for mortgage to millennials
      • Mortgage Calculator Modification – What Is?
      • Mortgage Calculator Canada: Rates Are Rising
      • Mortgage Calculator Home – Is it time to repair your own home mortgage?
      • Mortgage Calculator
      • Mortgage Calculator Rates Today April 3
      • Mortgage Calculator Online
      • Mortgage Calculator Coronavirus: UK mortgage market goes into lockdown
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    • Why Fintech Zoom?
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      • Ask for Proposal
  • Insurtech
    • Insurtech “Best of…”
      • Best Life Insurance of 2020
      • The Best Renters Insurance Companies 2020
      • Best Pet Insurance Providers of 2020
      • Best Home Insurance Companies for 2020
      • Best Car Insurance Quotes Online
      • Best Homeowners Insurance Companies of 2020
    • Insurtech Guides
      • Insurance will not cover coronavirus losses
  • Lifestyle
    • Real Estate
      • Aston Martin Residences
      • The Best Miami Luxury Homes
    • Entertainment
      • Gambling
        • Understanding Different Types Of Online Slots
        • How to Read Odds: NBA Odds
        • Online Casinos
        • Betting
          • US Betting Sites
          • UK Betting Sites
          • Asia Betting Sites
          • The Best Sports Betting Sites
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          • NFL Betting Sites In 2021
      • Gaming
        • GameStop
        • Roblox
          • Is Roblox shutting down? Vs. Robox will be listed NYSE
      • Music
        • Spotify
    • Luxury
      • Most Expensive Watches
      • Best Luxury Clothing Brands
      • Best Luxury SUVs for 2020
      • Porsche
      • Luxury Yatchs
      • Best Luxury Cars
      • Best Luxury Sports Car
      • Best Electric Cars
      • Best Luxury Yoga Retreats
      • The Best Luxury Sports Cars
      • Best Time to Buy a Car
    • Health
      • Sex
      • Covid-19
        • Direct Payments in coronavirus
    • Tech
      • iPhone 12
  • Loans
    • Loans Guides
      • First time loan with no credit
      • Find the Best Private Lender for Personal Loans
      • Emergency personal loans for veterans
      • Fafsa deadline
      • Cash Loans
      • Bad Credit Loans
      • Bad Credit Loans Guaranteed Approval
      • Merrill Lynch Benefits
      • Loans CLO Pain Just Starting With Leveraged loan Rating Cuts
      • Can you get a loan without a bank account?
    • Loans “Best of….”
      • Best place to get an auto loan
      • Best Loan for Students – The Best Private Student Loans of 2020
      • Best Student Loan Refinance of 2020
      • Best Business Loan Lenders of 2020
      • Best Personal Loans of 2020
      • Best Auto Loan Rates for 2020
      • Best payday loans 2020
      • Best Online Loans for Bad Credit 2020
    • Loans Calculators
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      • Loan Calculator
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      • FHA loan calculator
      • Auto Loan Calculator
      • Boat Loan Calculator
    • Loans Companies
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      • Rocket Loans
      • Nelnet Student Loans
      • Wells Fargo Student Loans
      • Discover Student Loans
      • AES Student Loans
      • Amigo Loans
      • Likely Loans
      • Tesco Loans
      • Sunny Loans
      • Great Lakes Students Loans
      • Caliber Home Loans
    • Loans Types
      • Payday Loans Bad Credit
      • Online Loans
      • Personal Loan
      • Personal loans for debt consolidation 2020
      • Payday Loans
      • Auto Loan
      • Student Loans Calculator: Pause Scholar mortgage Funds
      • Payday Loans
  • Cryptocurrencies
    • Crypto “Best Of…”
      • Best Crypto Wallets 2020
      • Best Crypto Hardware Wallets of 2020
      • Best Cryptocurrency Exchange 2021
      • Best Crypto to Invest in
      • Greatest Cryptocurrency Tax Software program 2020
      • Best Crypto Trading Bot
      • Best Cryptocurrency Exchanges | April 2020
    • Wallets
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      • Crypto Exchange News
      • Exchange Fee
      • Crypto Exchange Ranking
    • Services – ICO
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      • ICO – Premium Listing
      • ICO Calendar
      • Greatest ICO itemizing websites ICO Score Businesses (2019) | Cryptocurrency ICO Checklist | ICO Calendar
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      • ICO – Connect Investors
      • Airdrops News
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      • Binance Coin
      • COINBASE
    • Top Cryptocurrencies
      • Tether
      • Bitcoin Cash
      • Dogecoin
      • Litecoin
      • Bitcoin
        • Bitcoin Guides
          • Bitcoin ATM near me
          • How to get a lot of bitcoin for free?
          • Bitcoin BTC Price
          • How to Buy Bitcoin
          • Bitcoin
          • Where to buy Bitcoin?
          • Bitcoin Price Guide
          • How to Mine Bitcoin on PC
          • Bitcoin Halving
          • How Long does it Take to Mine 1 Bitcoin?
          • What can you Buy with Bitcoin?
          • Easiest Way to Buy Bitcoin
          • Bitcoin Hoje
          • Bitcoin Halving
          • How to Make Money with Bitcoin
          • Bitcoin Price Prediction
          • Bitcoin Tax
          • Bitcoin Value
          • Bitcoin for Beginners
          • Mercado Bitcoin
        • Bitcoin Calculator
          • BTC to USD Converter
          • Bitcoin Preev
        • Bitcoin “Best of…”
          • 23 Best Place to Buy Bitcoin Online 2020
          • Bitcoin Betting
          • Best Bitcoin Sports Betting Sites 2020
        • Buy Bitcoin
          • Buy Bitcoin With Gift Card
          • Buy Bitcoin with Credit Card
          • Buy Bitcoin Cash
          • Buy Bitcoin Anonymously
          • Buy Bitcoin with credit card
          • Buy Bitcoin with Prepaid Card
          • Buy Bitcoin with Paypal
          • Buy Bitcoin Near Me
          • Buy and Sell Bitcoin
          • Buy Bitcoin: Best Ways to Buy BTC Instantly
          • Buy Bitcoin at Walmart
          • Buy Bitcoin ATM
          • Buy Bitcoin Through Paypal
          • Buy Bitcoin Without ID
        • Bitcoin Price
          • Bitcoin Price USD
          • Bitcoin Price Live
          • Bitcoin Price Live Ticker
          • BTC to USD
          • Price of Bitcoin
          • Price Charts – Bitcoin Price
          • Bitcoin 가격
          • Bitcoin Price Prediction
        • Bitcoin News
          • Current Bitcoin News
            • Bitcoin Price Analysis is now value as a lot as PayPal
            • Bitcoin Price Volume Decline with Lowering Volatility
      • Ethereum
        • Ethereum News
        • Ethereum Worth
      • Ripple
        • Ripple Price
        • Ripple News
        • Ripple
  • News
    • Fintech News Today
    • News
      • Mortgage rates today, April 3, 2020 plus reviews
        • cmc currency details
          • cmc exchange details
            • Shortcodes
      • Microsoft Vulnerability: Hundreds of Microsoft Servers Contaminated By Crypto-Mining Botnet Since 2018
        • Cision PR Newswire
        • Coupons – Best websites
          • Aeromexico Rewards Chart
          • Get Avios Points Free
      • Today Bitcoin Price at $6,800 USD
      • Pandemic Is Changing BTC Usage in ‘Unexpected Ways’
      • Macropay on Alternative & local payment methods that are reshaping global e-commerce
      • Bank of America is preparing for a flood of Applications to Small-Business Loan
      • Microsoft might be the best tech stock in this market
      • US Airlines To Work Collectively, Consolidate Flights
      • Bank of America maintaining business continuity and protecting the bottom line
      • US long-term mortgage rates drop
      • Bitcoin Price Bulls have been rejected at $7,000
      • Stock Market: 4 Top Stock Trades for Wednesday: NVDA, AVGO, BAC, IQ
      • Stock Market April 2 – Edge Higher; Oil Surges, Bonds Fall, Dollar Rose
      • Chase bank will raise up to $10 billion
        • Bitcoin Price Simply Surged to $6,500 After Over 10% Weekend Crash
        • Today Bitcoin Price at $7,000: BTC Leaps to Retest $7,000
        • Bank of America agreed to allow 50,000 mortgage customers to defer payments
      • Bitcoin Price Prediction April: Three Key Causes Why BTC May Plunge Beneath $5,000
        • Roll up the Sleeves! American Airlines was down -10.34%
        • Mortgage calculator rates today April 2, 2020
        • Mortgage Calculator Small businesses: SB have ‘a million inquiries’ regarding check help loans
        • Bitcoin Price Today April 1 – Bitcoin Takes Tumble
          • With Bank of America card you can request a payment deferral online
            • Bank of America fields 150,000 installment deferral demands
          • Coronavirus – Travel Insurance no cover cancellations
            • Bank of America said it won’t cut any positions
        • Bitcoin Price Today April 2 – BTC rise to $6,700
        • Mortgage calculator rates today March 31, 2020
        • Bitcoin Price Momentum Sign Reverses, Bull Run Lastly Inbound?
        • Bitcoin Price Recovering After a Sharp Decline
        • Fintech News Airbnb – How hosts are fighting back against Covid-19 fallout
        • Market Stock Boeing – Challenging Times Ahead for Boeing Stock
      • Bank of America U.S. Minimum Hourly Wage Reaches $20
        • Bitcoin Price Bulls – is Forming a Bull Cross After Rallying to $6,500
        • P2P Crowdlending – Average Interest Rate 18%
        • $633 Million BTC Transferred For Simply $0.26 Payment
      • Prime ICO Advertising and marketing Companies
      • Bank of America will provide up to $250 million
      • Bank of America VC: You tend to do the wrong thing at the wrong time
        • Bitcoin Price Jump as Coronavirus Curve Begins to Flatten
          • Bitcoin Price Today April 3
          • Bitcoin Price Is Sometimes Bullish in Q2
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JNJ, NVS Q4 Earnings, MRK & LLY’s Coronavirus Updates

James Albert by James Albert
January 29, 2021
in Merck
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Home » JNJ, NVS Q4 Earnings, MRK & LLY’s Coronavirus Updates

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This week, J&J JNJ and Novartis NVS announced their fourth-quarter 2020 results. The European Commission granted approvals to Merck’s MRK Keytruda, AbbVie’s ABBV Rinvoq and Pfizer’s PFE Bavencio for expanded use. Merck ended the development of its COVID-19 vaccine candidates while Lilly LLY announced promising data from a study evaluating the combination of its COVID-19 antibodies.

Recap of the Week’s Most Important Stories

Earnings Update: J&J beat fourth-quarter estimates for earnings as well as sales. Its Pharmaceuticals unit continued to do well. Meanwhile, increasing demand for its Consumer Health products and continued procedure recovery in Medical Devices provided top-line support. Importantly, J&J’s guidance for 2021 topped investor expectations.

Novartis’ earnings and sales missed the Zacks Consensus Estimate. Sales in the Innovative Medicines division rose 1% at constant currency while that in the Sandoz division were flat. The company issued a grim outlook for 2021, warning of challenges ahead in the first half of the year due to the ongoing coronavirus pandemic.

Merck Ends COVID-19 Vaccine Development: Merck said it is discontinuing development of its two COVID-19 vaccine candidates, V590 and V591, which were in early-stage studies. Merck took the decision due to inferior immune responses observed for patients given the two vaccines in phase I studies compared to those seen in patients who were infected naturally and those reported for other COVID-19 vaccines. V590 was being developed in collaboration with International AIDS Vaccine Initiative.

Merck will however continue to develop its two therapeutics for COVID-19, its oral antiviral candidate molnupiravir/MK-4482 (phase II/III) and biological therapeutic, MK-7110 (phase III). MK-4482 is being developed in collaboration with Ridgeback Bio. Two pivotal studies are evaluating the candidate in non-hospitalized adult COVID-19 patients or hospitalized adult COVID-19 patients. For MK-7110, Merck has a supply agreement with the U.S. government to advance its manufacturing and initial distribution.

The European Commission granted approval to Keytruda as first-line treatment for metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer. Keytruda is already approved to treat MSI-H or dMMR colorectal cancer in patients whose cancer has progressed following treatment with fluoropyrimidine, oxaliplatin, and irinotecan. The FDA had granted approval for first line-setting for MSI-H or dMMR colorectal cancer in June

EU Approval to AbbVie’s Rinvoq for Two New Indications: The European Commission granted approval to AbbVie’s JAK inhibitorRinvoq for expanded use in two additional rheumatic indications, active psoriatic arthritis and active ankylosing spondylitis. Rinvoq is presently approved to treat rheumatoid arthritis in Europe. Regulatory applications seeking approval of Rinvoq for these two indications as well as atopic dermatitis are under review in the United States.

Promising Data on Lilly’s COVID-19 Antibody Combo: Lilly announced new data from the phase III BLAZE-1 study, which showed that a combination of its COVID-19 antibodies, bamlanivimab (LY-CoV555) and etesevimab (LY-CoV016) reduced risk of COVID-19 hospitalizations and death by 70% in high-risk patients recently diagnosed with COVID-19. The study, thus, met its primary endpoint. The antibody combination (both at doses of 2,800 mg) also demonstrated statistically significant improvements on all key secondary endpoints, indicating that the combination reduced viral load and accelerated symptom resolution.

Bamlanivimab was granted Emergency Use Authorization (EUA) by the FDA in November for the treatment of patients at high risk for progressing to severe COVID-19 illness or hospitalization based on data from the BLAZE-1 study. A request to grant EUA to bamlanivimab/etesevimab combination to treat mild-to-moderate COVID-19 in high-risk patients is also under review with the FDA.

Meanwhile, Lilly announced a deal with Vir Biotech and Glaxo to expand its ongoing BLAZE-4 study to evaluate bamlanivimab (700mg) with Vir Biotech/Glaxo’s investigational COVID-19 antibody, VIR-7831 (500mg) in low-risk patients with mild-to-moderate COVID-19. A phase II/III study is ongoing on VIR-7831 for the early treatment of COVID-19 in adults at high risk of hospitalization.

Lilly in-licensed exclusive rights for chronic pain drug candidate, AK1780 from Japan’s Asahi Kasei Pharma for an upfront payment of $20 million. Per the terms of the deal, Lilly will take care of future global development and regulatory activities for AK1780 while Asahi Kasei Pharma will just retain the right to promote the candidate in Japan and China. Meanwhile, Asahi Kasei Pharma will be eligible to receive up to $210 million in potential development and regulatory milestones

Pfizer’s Bavencio Gets EU Approval for Expanded Use: The European Commission approved Pfizer’s PD-L1 inhibitor Bavencio for first-line maintenance treatment of locally advanced or metastatic urothelial carcinoma (UC). Bavencio was approved in the United States for first-line maintenance treatment of advanced UC in June last year. Bavencio is already approved for patients with locally advanced or metastatic UC who have disease progression during or following platinum-containing chemotherapy. The approval for first-line use was based on positive data from the phase III JAVELIN Bladder 100 study.

Pfizer announced co-primary endpoint results from a post-marketing required safety study on Xeljanz in patients with rheumatoid arthritis (RA). The study failed to meet the co-primary endpoints of showing non-inferiority of Xeljanz to a TNF inhibitor with regard to major adverse cardiovascular events (MACE) and malignancies. Xeljanz is presently approved for four indications, RA, active psoriatic arthritis, moderately to severely active ulcerative colitis and active polyarticular course juvenile idiopathic arthritis

Pfizer & BioNTech signed an advance purchase agreement with COVAX to supply the latter with up to 40 million doses of its COVID-19 vaccine in 2021. The doses will be delivered throughout the year with the first deliveries taking place in the first quarter.

AstraZeneca’s Calquence Shows Superiority to Imbruvica in CLL Study: AstraZeneca’s (AZN) leukemia drug, Calquence met the primary efficacy endpoint in a head-to-head phase III study (ELEVATE-RR) evaluating it against AbbVie/J&J’s Imbruvica (ibrutinib) for previously treated chronic lymphocytic leukemia patients. The data demonstrated that treatment with Calquence led non-inferior progression-free survival (PFS), the primary endpoint, in such patients compared to Imbruvica. The study also met a key secondary endpoint for safety by showing that treatment with Calquence led to statistically significantly lower incidence of atrial fibrillation compared to Imbruvica.

The NYSE ARCA Pharmaceutical Index declined 0.5% in the last five trading sessions.

Large Cap Pharmaceuticals Industry 5YR % Return

Large Cap Pharmaceuticals Industry 5YR % Return

Large Cap Pharmaceuticals Industry 5YR % Return

Here’s how the eight major stocks performed in the last five trading sessions.

Last week, J&J recorded the maximum gain (4.6%) while AbbVie declined the most (6.3%).

In the past six months, Lilly recorded the maximum gain (37.3%) while AstraZeneca declined the most (10.1%).

(See the last pharma stock roundup here: FDA Nod to MRK, (AZN), JNJ, GSK Drugs, LLY’s New Antibody Deal)

What’s Next in the Pharma World?

Watch out for fourth-quarter and full-year 2020 earnings of Merck, Pfizer, Abbvie and others and pipeline and regulatory updates next week.

The Hottest Tech Mega-Trend of All

Last year, it generated $24 billion in global revenues. By 2020, it’s predicted to blast through the roof to $77.6 billion. Famed investor Mark Cuban says it will produce “”the world’s first trillionaires,”” but that should still leave plenty of money for regular investors who make the right trades early.

See Zacks’ 3 Best Stocks to Play This Trend >>

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report

Johnson & Johnson (JNJ) : Free Stock Analysis Report

AstraZeneca PLC ((AZN)) : Free Stock Analysis Report

Pfizer Inc. (PFE) : Free Stock Analysis Report

Merck & Co., Inc. (MRK) : Free Stock Analysis Report

Eli Lilly and Company (LLY) : Free Stock Analysis Report

Novartis AG (NVS) : Free Stock Analysis Report

AbbVie Inc. (ABBV) : Free Stock Analysis Report

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James Albert

James Albert is a personal-finance analist for FintechZoom and is based in New York. Contact: james.albert@fintechzoom.com

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